Are maternal antiplatelet antibodies a prothrombotic condition leading to miscarriage?
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چکیده
منابع مشابه
Are maternal antiplatelet antibodies a prothrombotic condition leading to miscarriage?
Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is a condition characterized by thrombocytopenia in the newborn. If severe, the thrombocytopenia can lead to intracranial hemorrhage. FNAIT arises when maternal antibodies specific for platelet antigens, most commonly β3 integrin, cross the placenta and destroy fetal platelets. Surprisingly, few cases of FNAIT are associated with antibodies...
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In 1990, an association between thyroid antibody positivity and spontaneous miscarriage was first reported. A generation has passed since the initial observation. Over that time a robust literature has developed which has confirmed the initial finding and expanded upon it. The present paper reviews the literature that has been generated over the last twenty years on the following topics: (1) th...
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BACKGROUND It is well known that miscarriage risk increases with age. However, studies usually investigate only maternal age effects. We investigated both maternal age and paternal age effects on miscarriage risk to provide insight into this frequent reproductive failure. METHODS The last planned pregnancies (n = 3174) that ended in a birth or miscarriage were analysed in a retrospective popu...
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the TAFI gene and resulting in the Thr325Ile substitution is associated with TAFI plasma levels, just like other SNPs in and around this gene. Presently, it is not known which SNP is/are responsible for this effect on TAFI levels. On the other hand, studies using recombinant proteins have demonstrated a functional effect of the Thr325Ile substitution on the stability of activated TAFI resulting...
متن کاملMaternal serum inhibin A levels are a marker of a viable trophoblast in incomplete and complete miscarriage.
OBJECTIVE From early gestation the human trophoblast secretes large amounts of inhibin A and activin A, and their measurement provides a value for predicting the outcome in women who become pregnant after assisted reproductive techniques. The aim of the study was to investigate the putative role of maternal serum inhibin A and activin A levels as markers of a viable trophoblast in women who mis...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2011
ISSN: 0021-9738
DOI: 10.1172/jci60749